Control of mRNA Translation by Versatile ATP-Driven Machines.
Trends Biochem Sci
; 44(2): 167-180, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30527974
ABSTRACT
Translation is organized in a cycle that requires ribosomal subunits, mRNA, aminoacylated transfer RNAs, and myriad regulatory factors. As soon as translation reaches a stop codon or stall, a termination or surveillance process is launched via the release factors eRF1 or Pelota, respectively. The ATP-binding cassette (ABC) protein ABCE1 interacts with release factors and coordinates the recycling process in Eukarya and Archaea. After splitting, ABCE1 stays with the small ribosomal subunit and emerges as an integral part of translation initiation complexes. In addition, eEF3 and ABCF proteins control translation by binding at the E-site. In this review, we highlight advances in the fundamental role of ABC systems in mRNA translation in view of their collective inner mechanics.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Trifosfato de Adenosina
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Alemanha