Inhibition of LPS-induced brain injury by NR2B antagonists through reducing assembly of NR2B-CaMKII-PSD95 signal module.

Song, Yuanjian; Zhao, Xiaofang; Wang, Di; Zheng, Yi; Dai, Chunxiao; Guo, Mengyuan; Qin, Li; Wen, Xiangru; Zhou, Xiaoyan; Liu, Zhian

Song, Yuanjian; Zhao, Xiaofang; Wang, Di; Zheng, Yi; Dai, Chunxiao; Guo, Mengyuan; Qin, Li; Wen, Xiangru; Zhou, Xiaoyan; Liu, Zhian.

Afiliação

Song Y; a Jiangsu Key Laboratory of Brain Disease Bioinformation , Xuzhou Medical University , Xuzhou , Jiangsu , People's Republic of China.
Zhao X; b Department of Genetics , Research Center for Neurobiology Xuzhou Medical University , Xuzhou , Jiangsu , People's Republic of China.
Wang D; c The Graduate School Xuzhou Medical University , Xuzhou , Jiangsu , People's Republic of China.
Zheng Y; c The Graduate School Xuzhou Medical University , Xuzhou , Jiangsu , People's Republic of China.
Dai C; a Jiangsu Key Laboratory of Brain Disease Bioinformation , Xuzhou Medical University , Xuzhou , Jiangsu , People's Republic of China.
Guo M; d Department of Biology , Illinois Institute of Technology , Chicago , IL , USA.
Qin L; c The Graduate School Xuzhou Medical University , Xuzhou , Jiangsu , People's Republic of China.
Wen X; c The Graduate School Xuzhou Medical University , Xuzhou , Jiangsu , People's Republic of China.
Zhou X; c The Graduate School Xuzhou Medical University , Xuzhou , Jiangsu , People's Republic of China.
Liu Z; b Department of Genetics , Research Center for Neurobiology Xuzhou Medical University , Xuzhou , Jiangsu , People's Republic of China.

Immunopharmacol Immunotoxicol ; 41(1): 86-94, 2019 Feb.

Article em En | MEDLINE | ID: mdl-30604645

Assuntos

Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo; Proteína 4 Homóloga a Disks-Large/metabolismo; Lobo Frontal/efeitos dos fármacos; Hipocampo/efeitos dos fármacos; Lipopolissacarídeos/toxicidade; Fenóis/farmacologia; Piperidinas/farmacologia; Receptores de N-Metil-D-Aspartato/antagonistas & inibidores; Animais; Lobo Frontal/imunologia; Lobo Frontal/metabolismo; Hipocampo/imunologia; Hipocampo/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Transdução de Sinais

Palavras-chave

4. JNKs; LPS; NR2B antagonists; NR2BCaMKIIPSD95 signal module; Neuroinflammation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenóis / Piperidinas / Lipopolissacarídeos / Receptores de N-Metil-D-Aspartato / Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina / Proteína 4 Homóloga a Disks-Large / Lobo Frontal / Hipocampo Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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