High-intensity breastfeeding improves insulin sensitivity during early post-partum period in obese women with gestational diabetes.
Diabetes Metab Res Rev
; 35(4): e3127, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30635961
ABSTRACT
AIM:
To investigate whether high-intensity breastfeeding (HIB) reduces insulin resistance during early post-partum period in women with gestational diabetes (GDM), independent of post-partum weight change (PWC). MATERIALS ANDMETHODS:
In this multicentre prospective study, we included Japanese women with GDM who underwent a 75-g oral glucose tolerance test (OGTT) during early post-partum. We measured plasma insulin during OGTT to obtain a homeostasis model of assessment of insulin resistance (HOMA-IR). We defined the condition in which infants were fed by breastfeeding alone or greater than or equal to 80% of the volume as HIB, and other statuses, including partial and nonbreastfeeding, as non-HIB. We investigated the association between post-partum HOMA-IR and the breastfeeding status after adjusting for confounders including PWC.RESULTS:
Among 222 women with GDM who underwent the OGTT at 7.9 ± 2.3 weeks post-partum with a PWC of -7.8 ± 3.4 kg, although the rate of abnormal glucose tolerance (prediabetes and diabetes) did not differ between the groups (33% vs 32%), the HOMA-IR in the HIB women (n = 166) was significantly lower than that in the non-HIB women (n = 56) (1.12 ± 0.85 vs 1.72 ± 1.43, P = 0.0002). The effect of the HIB was independently associated with lower HOMA-IR after adjusting for confounders including PMC. However, the subgroup analysis according to their pre-pregnancy obesity states showed that the effect was seen only in the obese subjects (BMI ≥ 25).CONCLUSIONS:
In obese Japanese women with GDM, HIB has a significant effect in reducing insulin resistance during early post-partum, independent of the post-partum weight loss.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Aleitamento Materno
/
Resistência à Insulina
/
Diabetes Gestacional
/
Intolerância à Glucose
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Diabetes Mellitus Tipo 2
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Japão