A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.

de Vries, Paul S; Sabater-Lleal, Maria; Huffman, Jennifer E; Marten, Jonathan; Song, Ci; Pankratz, Nathan; Bartz, Traci M; de Haan, Hugoline G; Delgado, Graciela E; Eicher, John D; Martinez-Perez, Angel; Ward-Caviness, Cavin K; Brody, Jennifer A; Chen, Ming-Huei; de Maat, Moniek P M; Frånberg, Mattias; Gill, Dipender; Kleber, Marcus E; Rivadeneira, Fernando; Soria, José Manuel; Tang, Weihong; Tofler, Geoffrey H; Uitterlinden, André G; van Hylckama Vlieg, Astrid; Seshadri, Sudha; Boerwinkle, Eric; Davies, Neil M; Giese, Anne-Katrin; Ikram, M Kamran; Kittner, Steven J; McKnight, Barbara; Psaty, Bruce M; Reiner, Alex P; Sargurupremraj, Muralidharan; Taylor, Kent D; Fornage, Myriam; Hamsten, Anders; März, Winfried; Rosendaal, Frits R; Souto, Juan Carlos; Dehghan, Abbas; Johnson, Andrew D; Morrison, Alanna C; O'Donnell, Christopher J; Smith, Nicholas L

de Vries, Paul S; Sabater-Lleal, Maria; Huffman, Jennifer E; Marten, Jonathan; Song, Ci; Pankratz, Nathan; Bartz, Traci M; de Haan, Hugoline G; Delgado, Graciela E; Eicher, John D; Martinez-Perez, Angel; Ward-Caviness, Cavin K; Brody, Jennifer A; Chen, Ming-Huei; de Maat, Moniek P M; Frånberg, Mattias; Gill, Dipender; Kleber, Marcus E; Rivadeneira, Fernando; Soria, José Manuel; Tang, Weihong; Tofler, Geoffrey H; Uitterlinden, André G; van Hylckama Vlieg, Astrid; Seshadri, Sudha; Boerwinkle, Eric; Davies, Neil M; Giese, Anne-Katrin; Ikram, M Kamran; Kittner, Steven J; McKnight, Barbara; Psaty, Bruce M; Reiner, Alex P; Sargurupremraj, Muralidharan; Taylor, Kent D; Fornage, Myriam; Hamsten, Anders; März, Winfried; Rosendaal, Frits R; Souto, Juan Carlos; Dehghan, Abbas; Johnson, Andrew D; Morrison, Alanna C; O'Donnell, Christopher J; Smith, Nicholas L.

Afiliação

de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Sabater-Lleal M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Huffman JE; Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.
Marten J; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Song C; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Pankratz N; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Bartz TM; The Framingham Heart Study, Framingham, MA.
de Haan HG; Center for Population Genomics, Veterans Affairs (VA) Boston Healthcare System, Jamaica Plain, MA.
Delgado GE; Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Eicher JD; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Martinez-Perez A; The Framingham Heart Study, Framingham, MA.
Ward-Caviness CK; Department of Medical Sciences and.
Brody JA; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Chen MH; Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN.
de Maat MPM; Department of Biostatistics, University of Washington, Seattle, WA.
Frånberg M; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Gill D; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Kleber ME; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Rivadeneira F; The Framingham Heart Study, Framingham, MA.
Soria JM; Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.
Tang W; National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, NC.
Tofler GH; Department of Medicine, University of Washington, Seattle, WA.
Uitterlinden AG; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
van Hylckama Vlieg A; The Framingham Heart Study, Framingham, MA.
Seshadri S; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Boerwinkle E; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Davies NM; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Giese AK; Department of Epidemiology and Biostatistics and.
Ikram MK; Department of Stroke Medicine, Imperial College London, London, United Kingdom.
Kittner SJ; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
McKnight B; Institute of Nutrition, Friedrich Schiller University Jena, Mannheim, Germany.
Psaty BM; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Reiner AP; Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.
Sargurupremraj M; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Taylor KD; Royal North Shore Hospital, University of Sydney, Sydney, Australia.
Fornage M; The Framingham Heart Study, Framingham, MA.
Hamsten A; Department of Neurology, Boston University, Boston, MA.
März W; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX.
Rosendaal FR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Souto JC; Human Genome Sequencing Center, College of Medicine, Baylor University, Houston, TX.
Dehghan A; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Johnson AD; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Morrison AC; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
O'Donnell CJ; Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Smith NL; Department of Neurology, School of Medicine, University of Maryland, Baltimore, MD.

Blood ; 133(9): 967-977, 2019 02 28.

Article em En | MEDLINE | ID: mdl-30642921

Assuntos

Isquemia Encefálica/etiologia; Fator VII/genética; Estudo de Associação Genômica Ampla; Proteínas de Membrana Transportadoras/genética; Proteínas de Neoplasias/genética; Polimorfismo de Nucleotídeo Único; Acidente Vascular Cerebral/etiologia; Isquemia Encefálica/metabolismo; Isquemia Encefálica/patologia; Proteínas Correpressoras; Estudos de Coortes; Doença da Artéria Coronariana/etiologia; Doença da Artéria Coronariana/metabolismo; Doença da Artéria Coronariana/patologia; Proteínas de Ligação a DNA; Fator VII/metabolismo; Feminino; Seguimentos; Loci Gênicos; Predisposição Genética para Doença; Humanos; Masculino; Proteínas de Membrana Transportadoras/metabolismo; Análise da Randomização Mendeliana; Pessoa de Meia-Idade; Proteínas de Neoplasias/metabolismo; Fenótipo; Prognóstico; Acidente Vascular Cerebral/metabolismo; Acidente Vascular Cerebral/patologia; Tromboembolia Venosa/etiologia; Tromboembolia Venosa/metabolismo; Tromboembolia Venosa/patologia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Fator VII / Isquemia Encefálica / Acidente Vascular Cerebral / Polimorfismo de Nucleotídeo Único / Estudo de Associação Genômica Ampla / Proteínas de Neoplasias Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google