Exome genotyping and linkage analysis identifies two novel linked regions and replicates two others for myopia in Ashkenazi Jewish families.

Simpson, Claire L; Musolf, Anthony M; Li, Qing; Portas, Laura; Murgia, Federico; Cordero, Roberto Y; Cordero, Jennifer B; Moiz, Bilal A; Holzinger, Emily R; Middlebrooks, Candace D; Lewis, Deyana D; Bailey-Wilson, Joan E; Stambolian, Dwight

Simpson, Claire L; Musolf, Anthony M; Li, Qing; Portas, Laura; Murgia, Federico; Cordero, Roberto Y; Cordero, Jennifer B; Moiz, Bilal A; Holzinger, Emily R; Middlebrooks, Candace D; Lewis, Deyana D; Bailey-Wilson, Joan E; Stambolian, Dwight.

Afiliação

Simpson CL; Department of Genetics, Genomics and Informatics and Department of Ophthalmology, University of Tennessee Health Science Center, 71 S. Manassas Room 417, Memphis, TN, 38163, USA.
Musolf AM; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr., Suite 1200, Baltimore, MD, 21224, USA.
Li Q; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr., Suite 1200, Baltimore, MD, 21224, USA.
Portas L; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr., Suite 1200, Baltimore, MD, 21224, USA.
Murgia F; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr., Suite 1200, Baltimore, MD, 21224, USA.
Cordero RY; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr., Suite 1200, Baltimore, MD, 21224, USA.
Cordero JB; Department of Genetics, Genomics and Informatics and Department of Ophthalmology, University of Tennessee Health Science Center, 71 S. Manassas Room 417, Memphis, TN, 38163, USA.
Moiz BA; Department of Genetics, Genomics and Informatics and Department of Ophthalmology, University of Tennessee Health Science Center, 71 S. Manassas Room 417, Memphis, TN, 38163, USA.
Holzinger ER; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr., Suite 1200, Baltimore, MD, 21224, USA.
Middlebrooks CD; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr., Suite 1200, Baltimore, MD, 21224, USA.
Lewis DD; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr., Suite 1200, Baltimore, MD, 21224, USA.
Bailey-Wilson JE; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr., Suite 1200, Baltimore, MD, 21224, USA.
Stambolian D; Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, 333 Cassell Dr., Suite 1200, Baltimore, MD, 21224, USA. jebw@mail.nih.gov.

BMC Med Genet ; 20(1): 27, 2019 01 31.

Article em En | MEDLINE | ID: mdl-30704416

Assuntos

Cromossomos Humanos/genética; Técnicas de Genotipagem/métodos; Judeus/genética; Miopia/genética; Cromossomos Humanos Par 1/genética; Cromossomos Humanos Par 11/genética; Cromossomos Humanos Par 7/genética; Cromossomos Humanos Par 8/genética; Exoma; Feminino; Predisposição Genética para Doença; Estudo de Associação Genômica Ampla; Humanos; Escore Lod; Masculino; Miopia/etnologia; Linhagem; RNA Longo não Codificante/genética

Palavras-chave

Family studies; Genetic linkage; Myopia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Judeus / Cromossomos Humanos / Técnicas de Genotipagem / Miopia Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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