Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours.

Youshani, A Saam; Rowlston, Samuel; O'Leary, Claire; Forte, Gabriella; Parker, Helen; Liao, Aiyin; Telfer, Brian; Williams, Kaye; Kamaly-Asl, Ian D; Bigger, Brian W

Youshani, A Saam; Rowlston, Samuel; O'Leary, Claire; Forte, Gabriella; Parker, Helen; Liao, Aiyin; Telfer, Brian; Williams, Kaye; Kamaly-Asl, Ian D; Bigger, Brian W.

Afiliação

Youshani AS; Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Rowlston S; Department of Neurosurgery, Salford Royal Hospital, Salford, UK.
O'Leary C; Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Forte G; Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Parker H; Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Liao A; Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Telfer B; Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Williams K; Division of Pharmacy and Optometry, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Kamaly-Asl ID; Division of Pharmacy and Optometry, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Bigger BW; Department of Neurosurgery, Royal Manchester Children's Hospital, Manchester, UK.

J Neuroinflammation ; 16(1): 25, 2019 Feb 05.

Article em En | MEDLINE | ID: mdl-30722781

Assuntos

Antineoplásicos Alquilantes/farmacologia; Células da Medula Óssea/efeitos dos fármacos; Células da Medula Óssea/efeitos da radiação; Neoplasias Encefálicas/imunologia; Bussulfano/farmacologia; Quimera; Imunidade Celular/efeitos dos fármacos; Imunidade Celular/efeitos da radiação; Inflamação/patologia; Quimera por Radiação; Animais; Células da Medula Óssea/imunologia; Linhagem Celular Tumoral; Citocinas/sangue; Feminino; Glioblastoma/patologia; Inflamação/induzido quimicamente; Antígenos Comuns de Leucócito/genética; Camundongos; Camundongos Endogâmicos C57BL; Transplante de Neoplasias

Palavras-chave

Chimeric mouse model; Glioblastoma; Head-shielded irradiation; Inflammation; Macrophages; Microglia; Non-myeloablative conditioning

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quimera por Radiação / Neoplasias Encefálicas / Bussulfano / Células da Medula Óssea / Quimera / Antineoplásicos Alquilantes / Imunidade Celular / Inflamação Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google