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A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes.
Riccardi, Keith A; Tess, David A; Lin, Jian; Patel, Roshan; Ryu, Sangwoo; Atkinson, Karen; Di, Li; Li, Rui.
Afiliação
  • Riccardi KA; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.).
  • Tess DA; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.).
  • Lin J; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.).
  • Patel R; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.).
  • Ryu S; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.).
  • Atkinson K; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.).
  • Di L; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.) Li.Di@pfizer.com.
  • Li R; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Worldwide R&D, Groton, Connecticut (K.A.R., J.L., R.P., S.R., K.A., L.D.) and Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts (D.A.T., R.L.) Rui.Li5@pfizer.com.
Drug Metab Dispos ; 47(5): 484-492, 2019 05.
Article em En | MEDLINE | ID: mdl-30787098
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Taxa de Depuração Metabólica / Hepatócitos / Fígado Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Taxa de Depuração Metabólica / Hepatócitos / Fígado Idioma: En Ano de publicação: 2019 Tipo de documento: Article