The plasmid-borne quinolone resistance protein QnrB, a novel DnaA-binding protein, increases the bacterial mutation rate by triggering DNA replication stress.

Li, Xiaojing; Zhang, Yujiao; Zhou, Xintong; Hu, Xinling; Zhou, Yixuan; Liu, Di; Maxwell, Anthony; Mi, Kaixia

Li, Xiaojing; Zhang, Yujiao; Zhou, Xintong; Hu, Xinling; Zhou, Yixuan; Liu, Di; Maxwell, Anthony; Mi, Kaixia.

Afiliação

Li X; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Zhang Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Zhou X; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 101408, China.
Hu X; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Zhou Y; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Liu D; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Maxwell A; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 101408, China.
Mi K; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

Mol Microbiol ; 111(6): 1529-1543, 2019 06.

Article em En | MEDLINE | ID: mdl-30838726

Assuntos

Replicação do DNA; Proteínas de Ligação a DNA/genética; Proteínas de Escherichia coli/genética; Escherichia coli/genética; Taxa de Mutação; DNA Bacteriano/metabolismo; Farmacorresistência Bacteriana/genética; Escherichia coli/efeitos dos fármacos; Perfilação da Expressão Gênica; Aptidão Genética; Mutação; Plasmídeos/genética; Quinolonas/farmacologia; Origem de Replicação; Sequenciamento Completo do Genoma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Escherichia coli / Proteínas de Ligação a DNA / Replicação do DNA / Escherichia coli / Taxa de Mutação Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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