Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Promote Fibroblast-to-Myofibroblast Differentiation in Inflammatory Environments and Benefit Cardioprotective Effects.

Shi, Yu; Yang, Yuqi; Guo, Qinyu; Gao, Qiuzhi; Ding, Ying; Wang, Hua; Xu, Wenrong; Yu, Bin; Wang, Mei; Zhao, Yuanyuan; Zhu, Wei

Shi, Yu; Yang, Yuqi; Guo, Qinyu; Gao, Qiuzhi; Ding, Ying; Wang, Hua; Xu, Wenrong; Yu, Bin; Wang, Mei; Zhao, Yuanyuan; Zhu, Wei.

Afiliação

Shi Y; 1 School of Medicine, Jiangsu University, Zhenjiang, China.
Yang Y; 2 Changzhou Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Guo Q; 1 School of Medicine, Jiangsu University, Zhenjiang, China.
Gao Q; 1 School of Medicine, Jiangsu University, Zhenjiang, China.
Ding Y; 1 School of Medicine, Jiangsu University, Zhenjiang, China.
Wang H; 3 The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Xu W; 1 School of Medicine, Jiangsu University, Zhenjiang, China.
Yu B; 2 Changzhou Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou, China.
Wang M; 1 School of Medicine, Jiangsu University, Zhenjiang, China.
Zhao Y; 1 School of Medicine, Jiangsu University, Zhenjiang, China.
Zhu W; 1 School of Medicine, Jiangsu University, Zhenjiang, China.

Stem Cells Dev ; 28(12): 799-811, 2019 06 15.

Article em En | MEDLINE | ID: mdl-30896296

Assuntos

Diferenciação Celular; Exossomos/transplante; Transplante de Células-Tronco Mesenquimais/métodos; Infarto do Miocárdio/terapia; Miócitos Cardíacos/citologia; Miofibroblastos/citologia; Animais; Apoptose; Células Cultivadas; Meios de Cultivo Condicionados/farmacologia; Exossomos/metabolismo; Humanos; Masculino; Células-Tronco Mesenquimais/metabolismo; Miócitos Cardíacos/efeitos dos fármacos; Miócitos Cardíacos/metabolismo; Miofibroblastos/metabolismo; Ratos; Ratos Sprague-Dawley; Cordão Umbilical/citologia

Palavras-chave

cardioprotection; exosomes; fibroblast; mesenchymal stem cells; myofibroblast differentiation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Miócitos Cardíacos / Transplante de Células-Tronco Mesenquimais / Exossomos / Miofibroblastos / Infarto do Miocárdio Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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