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Targeting Tyrosine kinases in Renal Cell Carcinoma: "New Bullets against Old Guys".
Alonso-Gordoa, Teresa; García-Bermejo, María Laura; Grande, Enrique; Garrido, Pilar; Carrato, Alfredo; Molina-Cerrillo, Javier.
Afiliação
  • Alonso-Gordoa T; Medical Oncology Department, The Ramón y Cajal Health Research Institute (IRYCIS), CIBERONC, Alcalá University, University Hospital Ramon y Cajal, 28034 Madrid, Spain. talonso@oncologiahrc.com.
  • García-Bermejo ML; Biomarkers and Therapeutic Targets Group and Core Facility, Ramón y Cajal Research Institute, (IRYCIS), 28034 Madrid, Spain. garciabermejo@gmail.com.
  • Grande E; Medical Oncology Department, MD Anderson Cancer Center, 28034 Madrid, Spain. egrande@oncomadrid.com.
  • Garrido P; Medical Oncology Department, The Ramón y Cajal Health Research Institute (IRYCIS), CIBERONC, Alcalá University, University Hospital Ramon y Cajal, 28034 Madrid, Spain. pilargarridol@gmail.com.
  • Carrato A; Medical Oncology Department, Ramón y Cajal Health Research Institute (IRYCIS). CIBERONC, Alcalá University, University Hospital Ramon y Cajal, 28034 Madrid, Spain. acarrato@telefonica.net.
  • Molina-Cerrillo J; Medical Oncology Department, The Ramón y Cajal Health Research Institute (IRYCIS), CIBERONC, Alcalá University, University Hospital Ramon y Cajal, 28034 Madrid, Spain. javier.molinace@gmail.com.
Int J Mol Sci ; 20(8)2019 Apr 17.
Article em En | MEDLINE | ID: mdl-30999623
ABSTRACT
Clear cell renal cell carcinoma (ccRCC) is the seventh most frequently diagnosed tumor in adults in Europe and represents approximately 2.5% of cancer deaths. The molecular biology underlying renal cell carcinoma (RCC) development and progression has been a key milestone in the management of this type of tumor. The discovery of Von Hippel Lindau (VHL) gene alterations that arouse in 50% of ccRCC patients, leads the identification of an intracellular accumulation of HIF and, consequently an increase of VEGFR expression. This change in cell biology represents a new paradigm in the treatment of metastatic renal cancer by targeting angiogenesis. Currently, there are multiple therapeutic drugs available for advanced disease, including therapies against VEGFR with successful results in patients´ survival. Other tyrosine kinases' pathways, including PDGFR, Axl or MET have emerged as key signaling pathways involved in RCC biology. Indeed, promising new drugs targeting those tyrosine kinases have exhibited outstanding efficacy. In this review we aim to present an overview of the central role of these tyrosine kinases' activities in relevant biological processes for kidney cancer and their usefulness in RCC targeted therapy development. In the immunotherapy era, angiogenesis is still an "old guy" that the medical community is trying to fight using "new bullets".
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Carcinoma de Células Renais / Transdução de Sinais / Inibidores da Angiogênese / Inibidores de Proteínas Quinases / Neoplasias Renais / Neovascularização Patológica Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Carcinoma de Células Renais / Transdução de Sinais / Inibidores da Angiogênese / Inibidores de Proteínas Quinases / Neoplasias Renais / Neovascularização Patológica Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Espanha