Your browser doesn't support javascript.
loading
Recent Advances on Reactive Oxygen Species-Responsive Delivery and Diagnosis System.
Ye, Huan; Zhou, Yang; Liu, Xun; Chen, Yongbing; Duan, Shanzhou; Zhu, Rongying; Liu, Yong; Yin, Lichen.
Afiliação
  • Ye H; Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou 215123 , China.
  • Zhou Y; Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou 215123 , China.
  • Liu X; Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou 215123 , China.
  • Chen Y; Department of Thoracic Surgery , The Second Affiliated Hospital of Soochow University , Suzhou 215004 , China.
  • Duan S; Department of Thoracic Surgery , The Second Affiliated Hospital of Soochow University , Suzhou 215004 , China.
  • Zhu R; Department of Thoracic Surgery , The Second Affiliated Hospital of Soochow University , Suzhou 215004 , China.
  • Liu Y; Department of Biomedical Engineering , University of Groningen and University Medical Center Groningen , Antonius Deusinglaan 1 , 9713 AV Groningen , The Netherlands.
  • Yin L; Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University , Suzhou 215123 , China.
Biomacromolecules ; 20(7): 2441-2463, 2019 07 08.
Article em En | MEDLINE | ID: mdl-31117357
ABSTRACT
Reactive oxygen species (ROS) play crucial roles in biological metabolism and intercellular signaling. However, ROS level is dramatically elevated due to abnormal metabolism during multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. By taking advantage of the discrepancy of ROS levels between normal and diseased tissues, a variety of ROS-sensitive moieties or linkers have been developed to design ROS-responsive systems for the site-specific delivery of drugs and genes. In this review, we summarized the ROS-responsive chemical structures, mechanisms, and delivery systems, focusing on their current advances for precise drug/gene delivery. In particular, ROS-responsive nanocarriers, prodrugs, and supramolecular hydrogels are summarized in terms of their application for drug/gene delivery, and common strategies to elevate or diminish cellular ROS concentrations, as well as the recent development of ROS-related imaging probes were also discussed.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Espécies Reativas de Oxigênio / Técnicas de Transferência de Genes / Doenças Neurodegenerativas / Senilidade Prematura / Diabetes Mellitus / Neoplasias Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Espécies Reativas de Oxigênio / Técnicas de Transferência de Genes / Doenças Neurodegenerativas / Senilidade Prematura / Diabetes Mellitus / Neoplasias Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China