[A phase II study of Futraful suppository in head and neck cancer].
Gan To Kagaku Ryoho
; 15(7): 2093-100, 1988 Jul.
Article
em Ja
| MEDLINE
| ID: mdl-3134860
ABSTRACT
A phase II study of FT-207 suppository (Futraful Suppository) for head and neck cancer was conducted at the Kagoshima University Hospital Dept. of Otorhinolaryngology and its 6 affiliated hospitals. Forty cases with head and neck cancer were entered in the trial, of which 37 were perfectly evaluable. Partial response (PR) (16.7%) was achieved in one of 6 patients with maxillary cancer, in 2 of 9 cases with oral cancer (22.2%), in one of 7 with laryngeal cancer (14.3%), in 3 of 13 with pharyngeal cancer, while 2 of the same 13 achieved a complete response (CR) (38.5%), for a total response rate of 24.3%. FT-207 suppository was continuously administered as standard, at a dose of 750 mg each twice daily, or 1,500 mg/day. The response rate was dose-dependent; 2 CR cases with a total dose of 105 g for administration over a total period of more than 150 days. Adverse effects appearing in 35.0% of the overall were mainly anorexia, nausea and vomiting; none of them, however, were serious.
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Base de dados:
MEDLINE
Assunto principal:
Tegafur
/
Neoplasias de Cabeça e Pescoço
Idioma:
Ja
Ano de publicação:
1988
Tipo de documento:
Article