Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss.
Am J Physiol Endocrinol Metab
; 317(4): E723-E730, 2019 10 01.
Article
em En
| MEDLINE
| ID: mdl-31408375
ABSTRACT
Pancreatic beta-cell death is a major factor in the pathogenesis of type 1 diabetes (T1D), but straightforward methods to measure beta-cell loss in humans are lacking, underlining the need for novel biomarkers. Using studies in INS-1 cells, human islets, diabetic mice, and serum samples of subjects with T1D at different stages, we have identified serum miR-204 as an early biomarker of T1D-associated beta-cell loss in humans. MiR-204 is a highly enriched microRNA in human beta-cells, and we found that it is released from dying beta-cells and detectable in human serum. We further discovered that serum miR-204 was elevated in children and adults with T1D and in autoantibody-positive at-risk subjects but not in type 2 diabetes or other autoimmune diseases and was inversely correlated with remaining beta-cell function in recent-onset T1D. Thus, serum miR-204 may provide a much needed novel approach to assess early T1D-associated human beta-cell loss even before onset of overt disease.
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
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MicroRNAs
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Diabetes Mellitus Tipo 1
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Células Secretoras de Insulina
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article