The clinical impact of family history of cancer in female never-smoker lung adenocarcinoma.
Lung Cancer
; 136: 15-22, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31421257
ABSTRACT
OBJECTIVES:
Accumulating evidence reveals the association between the risk of never-smoker lung cancer and family history of cancer. However, the clinicogenomic effect of family history of cancer in never-smoker lung cancer remains unknown. MATERIAL ANDMETHODS:
We screened 3,241 lung cancer patients who (a) underwent curative resection at National Cancer Center (Goyang, Korea) between 2001-2014, and (b) completed a pre-designed interview about family/smoking history at the time of diagnosis and identified 604 female never smoker lung adenocarcinoma. A positive family history of cancer [categorized as pulmonary cancer (FH-PC) or non-pulmonary cancer (FH-NPC)] was defined as a self-reported history of cancer in first-degree relatives. Survival data were followed up until January 2017. Multiplexed targeted next-generation sequencing was performed for genetic profiling.RESULTS:
Of 604 patients, 29.1% (nâ¯=â¯176) had a FH, including 132 (21.9%) with FH-NPC and 44 (7.3%) with FH-PC. Patients with the FH-NPC had a higher proportion of young patients (≤45 years) than those without the FH-NPC (FH-NPC, FH-PC, and no FH; 13.6%, 2.3%, and 8.2%, respectively; Pâ¯=â¯0.032). Patients with the FH-NPC had an increased risk of recurrence (hazard ratio [HR] 1.90; 95% confidence interval [CI] 1.40-2.56; P<0.001) and death (HR 1.67; 95% CI 1.18-2.37; P=0.004). In contrast, the FH-PC had no prognostic effect on recurrence (HR 1.23; 95% CI 0.71-2.15; Pâ¯=â¯0.456) and death (HR 0.93; 95% CI 0.45-1.91; P=0.838). Among three driver oncogene alterations, EGFR mutation was significantly associated with the FH-PC (53.8%, 84.1%, and 65.8%, respectively; Pâ¯=â¯0.016), ALK/ROS1/RET fusions was significantly associated with the FH-NPC (13.7%, 0.0%, and 5.0%, respectively; Pâ¯=â¯0.004), but KRAS mutation was not associated with any type of the FH (13.8% vs. 6.0% vs. 7.8%, respectively; Pâ¯=â¯0.288).CONCLUSION:
The type of family history of cancer was associated with distinct clinocogenomic subtypes and prognosis of never-smoker lung adenocarcinoma.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Suscetibilidade a Doenças
/
Adenocarcinoma de Pulmão
/
Não Fumantes
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article