Haploidentical hematopoietic stem cell transplantation in adults using the αßTCR/CD19-based depletion of G-CSF-mobilized peripheral blood progenitor cells.
Bone Marrow Transplant
; 54(Suppl 2): 698-702, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31431717
ABSTRACT
In patients with hematological malignancies at high risk for relapse, a mismatched hematopoietic stem cells transplants can be offered with no undue delay between decision-making and transplantation as virtually all patients have a full-haplotype mismatched member who could serve immediately as a donor. Using a T-cell depletion approach, these patients can benefit from a graft-vs-leukemia effect in the absence of both acute and chronic graft-vs-host disease. Over the past decade, efforts have concentrated on developing new conditioning regimens, optimizing the graft processing and improving the posttransplant immunological recovery. The innovative strategy based on the selective depletion of alpha/beta-positive T lymphocytes from G-CSF-mobilized peripheral blood precursor cells has shown very promising results in the setting of the pediatric transplantation. This paper reports the outcome in adult patients with hematological malignancies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Células-Tronco Hematopoéticas
/
Antígenos CD19
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Condicionamento Pré-Transplante
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Células-Tronco de Sangue Periférico
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Transplante Haploidêntico
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Itália