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Mutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumors.
Pang, Yuzhi; Xie, Feifei; Cao, Hui; Wang, Chunmeng; Zhu, Meijun; Liu, Xiaoxiao; Lu, Xiaojing; Huang, Tao; Shen, Yanying; Li, Ke; Jia, Xiaona; Li, Zhang; Zheng, Xufen; Wang, Simin; He, Yi; Wang, Linhui; Fletcher, Jonathan A; Wang, Yuexiang.
Afiliação
  • Pang Y; Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences-Changzheng Hospital Joint Center for Translational Medicine, Changzheng Hospital, Institutes for Translational Medicine, Chinese Academy of Sciences-Second Military Medical University, Shanghai Institute
  • Xie F; Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences-Changzheng Hospital Joint Center for Translational Medicine, Changzheng Hospital, Institutes for Translational Medicine, Chinese Academy of Sciences-Second Military Medical University, Shanghai Institute
  • Cao H; Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 200127 Shanghai, China.
  • Wang C; Department of Bone and Soft Tissue Sarcomas, Fudan University Shanghai Cancer Center, 200032 Shanghai, China.
  • Zhu M; Department of Oncology, Shanghai Medical College, Fudan University, 200032 Shanghai, China.
  • Liu X; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
  • Lu X; Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences-Changzheng Hospital Joint Center for Translational Medicine, Changzheng Hospital, Institutes for Translational Medicine, Chinese Academy of Sciences-Second Military Medical University, Shanghai Institute
  • Huang T; Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences-Changzheng Hospital Joint Center for Translational Medicine, Changzheng Hospital, Institutes for Translational Medicine, Chinese Academy of Sciences-Second Military Medical University, Shanghai Institute
  • Shen Y; Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031 Shanghai, China.
  • Li K; Department of Pathology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 200127 Shanghai, China.
  • Jia X; Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences-Changzheng Hospital Joint Center for Translational Medicine, Changzheng Hospital, Institutes for Translational Medicine, Chinese Academy of Sciences-Second Military Medical University, Shanghai Institute
  • Li Z; Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences-Changzheng Hospital Joint Center for Translational Medicine, Changzheng Hospital, Institutes for Translational Medicine, Chinese Academy of Sciences-Second Military Medical University, Shanghai Institute
  • Zheng X; Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences-Changzheng Hospital Joint Center for Translational Medicine, Changzheng Hospital, Institutes for Translational Medicine, Chinese Academy of Sciences-Second Military Medical University, Shanghai Institute
  • Wang S; Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences-Changzheng Hospital Joint Center for Translational Medicine, Changzheng Hospital, Institutes for Translational Medicine, Chinese Academy of Sciences-Second Military Medical University, Shanghai Institute
  • He Y; Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences-Changzheng Hospital Joint Center for Translational Medicine, Changzheng Hospital, Institutes for Translational Medicine, Chinese Academy of Sciences-Second Military Medical University, Shanghai Institute
  • Wang L; Department of Urology, No.1 Hospital of Jiaxing, 314000 Jiaxing, China.
  • Fletcher JA; Department of Urology, Changzheng Hospital, Second Military Medical University, 200003 Shanghai, China.
  • Wang Y; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; jfletcher@bwh.harvard.edu yxwang76@sibs.ac.cn.
Proc Natl Acad Sci U S A ; 116(45): 22746-22753, 2019 11 05.
Article em En | MEDLINE | ID: mdl-31636198
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Ativadoras de GTPase / Tumores do Estroma Gastrointestinal / Alvo Mecanístico do Complexo 1 de Rapamicina / Neoplasias Gastrointestinais / Mutação Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Ativadoras de GTPase / Tumores do Estroma Gastrointestinal / Alvo Mecanístico do Complexo 1 de Rapamicina / Neoplasias Gastrointestinais / Mutação Idioma: En Ano de publicação: 2019 Tipo de documento: Article