Molecular characterization of a Marek's disease virus strain detected in tumour-bearing turkeys.
Avian Pathol
; 49(2): 202-207, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-31702386
ABSTRACT
Marek's disease (MD) is a lymphoproliferative disease caused by Gallid alphaherpesvirus 2 (GaHV-2), which primarily affects chickens. However, the virus is also able to induce tumours in turkeys, albeit less frequently than in chickens. This study reports the molecular characterization of a GaHV-2 strain detected in a flock of Italian meat-type turkeys exhibiting visceral lymphomas. Sequencing and phylogenetic analysis of the meq gene revealed that the turkey GaHV-2 has molecular features of high virulence and genetic similarity with GaHV-2 strains recently detected in Italian commercial and backyard chickens. GaHV-2 is ubiquitous among chickens despite vaccination, and chicken-to-turkey transmission is hypothesized due to the presence of broilers in neighbouring pens.RESEARCH HIGHLIGHTS A GaHV-2 strain from Italian turkeys was molecularly characterized.The turkey strain presented molecular characteristics of high virulence in its meq gene.The turkey strain was closely related to previously detected chicken strains.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Perus
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Doença de Marek
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Herpesvirus Galináceo 2
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Neoplasias
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Itália