Association of vitamin D receptor TaqI and ApaI genetic polymorphisms with nephrolithiasis and end stage renal disease: a meta-analysis.
BMC Med Genet
; 20(1): 193, 2019 12 10.
Article
em En
| MEDLINE
| ID: mdl-31822280
ABSTRACT
BACKGROUND:
The deficiency of vitamin D receptor (VDR) or its ligand, vitamin D3, is linked to the development of renal diseases. The TaqI (rs731236) and ApaI (rs7975232) polymorphisms of VDR gene are widely studied for their association with renal disease risk. However, studies have largely been ambiguous.METHODS:
Meta-analysis was carried out to clarify the association of TaqI (2777 cases and 3522 controls) and ApaI (2440 cases and 3279 controls) polymorphisms with nephrolithiasis (NL), diabetic nephropathy (DN) and end stage renal disease (ESRD).RESULTS:
The VDR TaqI C-allele under allele contrast was significantly associated with ESRD in both fixed effect and random effect models, and ApaI C-allele with ESRD only under fixed effect model. Cochrane Q-test showed no evidence of heterogeneity for TaqI polymorphism and a significant heterogeneity for Apa I polymorphism. No publication bias was observed for both the polymorphisms.CONCLUSIONS:
The present meta-analysis identifies TaqI and ApaI polymorphisms of VDR gene as risk factors for renal diseases.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Desoxirribonucleases de Sítio Específico do Tipo II
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Receptores de Calcitriol
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Polimorfismo de Nucleotídeo Único
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Nefropatias Diabéticas
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Nefrolitíase
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Falência Renal Crônica
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Arábia Saudita