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Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus Aspergillus sp. HNMF114.
Kong, Fan-Dong; Zhang, Sheng-Liang; Zhou, Shuang-Qing; Ma, Qing-Yun; Xie, Qing-Yi; Chen, Jin-Ping; Li, Jiu-Hui; Zhou, Li-Man; Yuan, Jing-Zhe; Hu, Zhong; Dai, Hao-Fu; Huang, Xiao-Long; Zhao, You-Xing.
Afiliação
  • Kong FD; Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , People's Republic of China.
  • Zhang SL; Key Laboratory of Tropical Biological Resources of the Ministry of Education , Hainan University , Haikou 570228 , People's Republic of China.
  • Zhou SQ; Key Laboratory of Tropical Biological Resources of the Ministry of Education , Hainan University , Haikou 570228 , People's Republic of China.
  • Ma QY; Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , People's Republic of China.
  • Xie QY; Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , People's Republic of China.
  • Chen JP; Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , People's Republic of China.
  • Li JH; Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , People's Republic of China.
  • Zhou LM; Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , People's Republic of China.
  • Yuan JZ; Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , People's Republic of China.
  • Hu Z; Department of Biology, College of Science , Shantou University , Shantou 515063 , People's Republic of China.
  • Dai HF; Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , People's Republic of China.
  • Huang XL; Key Laboratory of Tropical Biological Resources of the Ministry of Education , Hainan University , Haikou 570228 , People's Republic of China.
  • Zhao YX; Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , People's Republic of China.
J Nat Prod ; 82(12): 3456-3463, 2019 12 27.
Article em En | MEDLINE | ID: mdl-31823605
ABSTRACT
Seven new quinazoline-containing indole alkaloids (1-7) named aspertoryadins A-G, along with nine known ones (8-16), were isolated from the marine-derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis. The structures of the new compounds were elucidated from spectroscopic data, X-ray diffraction analysis, ECD spectra analysis, and ECD calculations. Compound 1 bears an aminosulfonyl group in the structure, which is rarely encountered in natural products. Compounds 6, 7, and 13 exhibited quorum sensing inhibitory activity against Chromobacterium violaceum CV026 with MIC values of 32, 32, and 16 µg/well, respectively.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Aspergillus / Água do Mar / Alcaloides Indólicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Aspergillus / Água do Mar / Alcaloides Indólicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article