A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells.

Novarina, Daniele; Janssens, Georges E; Bokern, Koen; Schut, Tim; van Oerle, Noor C; Kazemier, Hinke G; Veenhoff, Liesbeth M; Chang, Michael

Novarina, Daniele; Janssens, Georges E; Bokern, Koen; Schut, Tim; van Oerle, Noor C; Kazemier, Hinke G; Veenhoff, Liesbeth M; Chang, Michael.

Afiliação

Novarina D; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Janssens GE; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Bokern K; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Schut T; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
van Oerle NC; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Kazemier HG; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Veenhoff LM; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Chang M; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Aging Cell ; 19(2): e13084, 2020 02.

Article em En | MEDLINE | ID: mdl-31854076

Assuntos

Sistemas de Transporte de Aminoácidos Básicos/genética; Senescência Celular/genética; Instabilidade Genômica/genética; Proteínas de Membrana/genética; Taxa de Mutação; Proteínas de Saccharomyces cerevisiae/genética; Saccharomyces cerevisiae/genética; Replicação do DNA/genética; Endonucleases Flap/genética; Ontologia Genética; Técnicas Genéticas; Mutagênese; Mutação; Acúmulo de Mutações; Complexo de Proteínas Formadoras de Poros Nucleares/genética; Saccharomyces cerevisiae/fisiologia; Endonucleases Específicas para DNA e RNA de Cadeia Simples/genética

Palavras-chave

genome stability; high-throughput screen; mutagenesis; mutation rate; replicative aging; yeast

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Senescência Celular / Sistemas de Transporte de Aminoácidos Básicos / Proteínas de Saccharomyces cerevisiae / Instabilidade Genômica / Taxa de Mutação / Proteínas de Membrana Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

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