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Clinical and Molecular Epidemiology of Invasive Haemophilus influenzae Serotype a Infections in Utah Children.
Crandall, Hillary; Christiansen, Jennifer; Varghese, Alyssa A; Russon, Adam; Korgenski, E Kent; Bengtson, Erika K; Dickey, Mandy; Killpack, Jarrett; Knackstedt, Elizabeth D; Daly, Judy A; Ampofo, Krow; Pavia, Andrew T; Blaschke, Anne J.
Afiliação
  • Crandall H; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Christiansen J; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Varghese AA; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Russon A; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Korgenski EK; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Bengtson EK; Pediatric Clinical Program, Intermountain Health Care, Salt Lake City, Utah, USA.
  • Dickey M; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Killpack J; Department of Microbiology, Primary Children's Hospital, Salt Lake City, Utah, USA.
  • Knackstedt ED; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Daly JA; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Ampofo K; Department of Microbiology, Primary Children's Hospital, Salt Lake City, Utah, USA.
  • Pavia AT; Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • Blaschke AJ; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
J Pediatric Infect Dis Soc ; 9(6): 650-655, 2020 Dec 31.
Article em En | MEDLINE | ID: mdl-31858115
ABSTRACT

BACKGROUND:

Following widespread use of the Haemophilus influenzae serotype b (Hib) vaccine, H. influenzae serotype a (Hia) has emerged as an important pathogen in children in some regions. We describe the clinical features and molecular epidemiology of invasive Hia disease in children in Utah over an 11-year period.

METHODS:

We identified cases of invasive Hia disease, defined as detection of Hia from a normally sterile site, in children aged <18 years from Utah between 2007 and 2017. Medical records were reviewed to determine demographic characteristics and clinical outcomes. Available Hia isolates were genotyped using multilocus sequence typing, and phylogenetic division was determined using sodC polymerase chain reaction. Presence of the putative virulence-associated IS1016-bexA duplication-deletion was evaluated.

RESULTS:

We identified 51 children with invasive Hia. The average annual incidence was 1.7 cases per 100 000 children aged <5 years; 4.8 cases per 100 000 children aged <1 year. The median age was 11.3 months. The most common clinical presentation was meningitis (53%), followed by pneumonia (14%) and septic arthritis (14%). Twenty-two children (43%) required admission to an intensive care unit; 1 died. Sequence type (ST) 62, phylogenetic division II isolates caused 75% (21/28) of disease. No isolates contained the virulence-associated IS1016-bexA duplication-deletion.

CONCLUSIONS:

Hia is a significant cause of severe invasive bacterial infection in Utah. The majority of infections were caused by ST62 isolates, a phylogenetic division II Hia type that lacks the IS1016-bexA duplication-deletion. Hia ST62 has not been commonly reported elsewhere, suggesting a unique molecular epidemiology in our population.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Haemophilus País/Região como assunto: America do norte Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Haemophilus País/Região como assunto: America do norte Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos