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Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi.
De Araújo, Julianna Siciliano; da Silva, Patrícia Bernardino; Batista, Marcos Meuser; Peres, Raiza Brandão; Cardoso-Santos, Camila; Kalejaiye, Titilola D; Munday, Jane C; De Heuvel, Erik; Sterk, Geert Jan; Augustyns, Koen; Salado, Irene G; Matheeussen, An; De Esch, Iwan; De Koning, Harry P; Leurs, Rob; Maes, Louis; Soeiro, Maria de Nazaré Correia.
Afiliação
  • De Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • da Silva PB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Batista MM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Peres RB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Cardoso-Santos C; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Kalejaiye TD; Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
  • Munday JC; Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
  • De Heuvel E; Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Sterk GJ; Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Augustyns K; Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium.
  • Salado IG; Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium.
  • Matheeussen A; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.
  • De Esch I; Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • De Koning HP; Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
  • Leurs R; Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines & Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Maes L; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.
  • Soeiro MNC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
J Antimicrob Chemother ; 75(4): 958-967, 2020 04 01.
Article em En | MEDLINE | ID: mdl-31860098
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Trypanosoma cruzi / Doença de Chagas Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tripanossomicidas / Trypanosoma cruzi / Doença de Chagas Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil