Co-Expression of Three Wild-Type 3R-Tau Isoforms Induces Memory Deficit via Oxidation-Related DNA Damage and Cell Death: A Promising Model for Tauopathies.

Xu, Cheng; Guo, Jing; Li, Li; Wang, Xin; Zhou, Qiuzhi; Sun, Dongsheng; Zhang, Shujuan; Li, Shihong; Ye, Jinwang; Liu, Yanchao; Liu, Enjie; Zeng, Peng; Wang, Xiaochuan; Yang, Ying; Wang, Jian-Zhi

Xu, Cheng; Guo, Jing; Li, Li; Wang, Xin; Zhou, Qiuzhi; Sun, Dongsheng; Zhang, Shujuan; Li, Shihong; Ye, Jinwang; Liu, Yanchao; Liu, Enjie; Zeng, Peng; Wang, Xiaochuan; Yang, Ying; Wang, Jian-Zhi.

Afiliação

Xu C; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Guo J; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Li L; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Wang X; Department of Physiology, Hubei University of Chinese Medicine, Wuhan, China.
Zhou Q; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Sun D; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Zhang S; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Li S; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Ye J; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Liu Y; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Liu E; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Zeng P; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Wang X; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Yang Y; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Wang JZ; Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.

J Alzheimers Dis ; 73(3): 1105-1123, 2020.

Article em En | MEDLINE | ID: mdl-31884489

Assuntos

Morte Celular/fisiologia; Dano ao DNA/fisiologia; Transtornos da Memória/metabolismo; Isoformas de Proteínas/metabolismo; Tauopatias/metabolismo; Proteínas tau/metabolismo; Animais; Modelos Animais de Doenças; Hipocampo/metabolismo; Hipocampo/patologia; Transtornos da Memória/genética; Camundongos; Neurônios/metabolismo; Neurônios/patologia; Estresse Oxidativo/fisiologia; Fosforilação; Isoformas de Proteínas/genética; Tauopatias/genética; Tauopatias/patologia; Proteínas tau/genética

Palavras-chave

3R-tau; DNA double-strand breaks; oxidative stress; tauopathies

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Morte Celular / Proteínas tau / Isoformas de Proteínas / Tauopatias / Transtornos da Memória Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google