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Neural Stem Cells.
Tuazon, Julian P; Castelli, Vanessa; Lee, Jea-Young; Desideri, Giovambattista B; Stuppia, Liborio; Cimini, Anna Maria; Borlongan, Cesar V.
Afiliação
  • Tuazon JP; Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA.
  • Castelli V; Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA.
  • Lee JY; Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA.
  • Desideri GB; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Stuppia L; Department of Psychological, Humanistic and Territorial Sciences, University G. D'Annunzio, Chieti, Italy.
  • Cimini AM; Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Borlongan CV; Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Temple University, Philadelphia, PA, USA.
Adv Exp Med Biol ; 1201: 79-91, 2019.
Article em En | MEDLINE | ID: mdl-31898782
ABSTRACT
Neural stem cell (NSC) transplantation has provided the basis for the development of potentially powerful new therapeutic cell-based strategies for a broad spectrum of clinical diseases, including stroke, psychiatric illnesses such as fetal alcohol spectrum disorders, and cancer. Here, we discuss pertinent preclinical investigations involving NSCs, including how NSCs can ameliorate these diseases, the current barriers hindering NSC-based treatments, and future directions for NSC research. There are still many translational requirements to overcome before clinical therapeutic applications, such as establishing optimal dosing, route of delivery, and timing regimens and understanding the exact mechanism by which transplanted NSCs lead to enhanced recovery. Such critical lab-to-clinic investigations will be necessary in order to refine NSC-based therapies for debilitating human disorders.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neurais Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neurais Idioma: En Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos