A pathogen-derived metabolite induces microglial activation via odorant receptors.

Lee, NaHye; Jae, YoonGyu; Kim, Minhyung; Cho, TaeHo; Lee, ChaeEun; Hong, Yu Ri; Hyeon, Do Young; Ahn, Sanghyun; Kwon, Hongmok; Kim, Kyul; Jung, Jae Hoon; Chae, Sehyun; Shin, Jeong-Oh; Bok, Jinwoong; Byun, Youngjoo; Hwang, Daehee; Koo, JaeHyung

Lee, NaHye; Jae, YoonGyu; Kim, Minhyung; Cho, TaeHo; Lee, ChaeEun; Hong, Yu Ri; Hyeon, Do Young; Ahn, Sanghyun; Kwon, Hongmok; Kim, Kyul; Jung, Jae Hoon; Chae, Sehyun; Shin, Jeong-Oh; Bok, Jinwoong; Byun, Youngjoo; Hwang, Daehee; Koo, JaeHyung.

Afiliação

Lee N; Department of New Biology, DGIST, Daegu, Korea.
Jae Y; Department of Brain and Cognitive Sciences, DGIST, Daegu, Korea.
Kim M; Department of New Biology, DGIST, Daegu, Korea.
Cho T; Department of Brain and Cognitive Sciences, DGIST, Daegu, Korea.
Lee C; Center for Plant Aging Research, DGIST, Daegu, Korea.
Hong YR; Department of New Biology, DGIST, Daegu, Korea.
Hyeon DY; Department of New Biology, DGIST, Daegu, Korea.
Ahn S; Department of New Biology, DGIST, Daegu, Korea.
Kwon H; Center for Plant Aging Research, DGIST, Daegu, Korea.
Kim K; Center for Plant Aging Research, DGIST, Daegu, Korea.
Jung JH; College of Pharmacy, Korea University, Sejong, Korea.
Chae S; College of Pharmacy, Korea University, Sejong, Korea.
Shin JO; Center for Plant Aging Research, DGIST, Daegu, Korea.
Bok J; Center for Plant Aging Research, DGIST, Daegu, Korea.
Byun Y; Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea.
Hwang D; Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea.
Koo J; College of Pharmacy, Korea University, Sejong, Korea.

FEBS J ; 287(17): 3841-3870, 2020 09.

Article em En | MEDLINE | ID: mdl-32003140

Assuntos

Furanos/farmacologia; Microglia/efeitos dos fármacos; Receptores Odorantes/fisiologia; Streptococcus pneumoniae/metabolismo; Animais; Receptor 1 de Quimiocina CX3C/genética; Células Cultivadas; Quimiotaxia/efeitos dos fármacos; Citocinas/biossíntese; Citocinas/genética; Furanos/isolamento & purificação; Regulação da Expressão Gênica/efeitos dos fármacos; Interações Hospedeiro-Patógeno; Ligantes; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Microglia/metabolismo; Modelos Moleculares; Estrutura Molecular; Peso Molecular; Fagocitose/efeitos dos fármacos; Ligação Proteica; Conformação Proteica; RNA Mensageiro/biossíntese; RNA Mensageiro/genética; Espécies Reativas de Oxigênio/metabolismo; Receptores Odorantes/genética; Transdução de Sinais; Superóxidos/metabolismo

Palavras-chave

microglial activation; non-olfactory expression; odorant receptor; pathogenic metabolite

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus pneumoniae / Receptores Odorantes / Microglia / Furanos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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