Anti-CV2/CRMP5 antibody-associated hemorrhagic leukoencephalomyelitis treated with steroids, intravenous immunoglobulin, plasmapheresis, and cyclophosphamide.
Mult Scler Relat Disord
; 40: 101964, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-32044694
ABSTRACT
Anti-CV2 or anti-collapsing response-mediator protein-5 (CRMP5) autoantibodies (anti-CV2/CRMP5-Ab) are associated with various paraneoplastic neurological disorders. The best therapy is typically removal of the underlying cancer. We describe a previously healthy elderly male who had no known malignancy. He presented with a demyelinating encephalomyelitis and later developed hemorrhagic changes on neuroimaging. He was treated with intravenous immunoglobulin (IVIG), intravenous steroids, and plasmapheresis; however, sustained clinical and radiographic stabilization and improvement only occurred following cyclophosphamide. He unexpectedly died of a cardiac arrest. postmortem, his serum paraneoplastic screen was found to be weakly positive for anti-CV2/CRMP5-Ab.
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MEDLINE
Assunto principal:
Autoanticorpos
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Leucoencefalite Hemorrágica Aguda
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Ciclofosfamida
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Hidrolases
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Fatores Imunológicos
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Proteínas Associadas aos Microtúbulos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article