The antifungal plant defensin HsAFP1 induces autophagy, vacuolar dysfunction and cell cycle impairment in yeast.

Struyfs, Caroline; Cools, Tanne L; De Cremer, Kaat; Sampaio-Marques, Belém; Ludovico, Paula; Wasko, Brian M; Kaeberlein, Matt; Cammue, Bruno P A; Thevissen, Karin

Struyfs, Caroline; Cools, Tanne L; De Cremer, Kaat; Sampaio-Marques, Belém; Ludovico, Paula; Wasko, Brian M; Kaeberlein, Matt; Cammue, Bruno P A; Thevissen, Karin.

Afiliação

Struyfs C; Centre of Microbial and Plant Genetics, KU Leuven, 3001 Leuven, Belgium; VIB Center for Plant Systems Biology, 9052 Ghent, Belgium.
Cools TL; Centre of Microbial and Plant Genetics, KU Leuven, 3001 Leuven, Belgium.
De Cremer K; Centre of Microbial and Plant Genetics, KU Leuven, 3001 Leuven, Belgium.
Sampaio-Marques B; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, 4700 Braga/Guimarães, Portugal.
Ludovico P; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, 4700 Braga/Guimarães, Portugal.
Wasko BM; Department of Pathology, University of Washington, 98195 Seattle, USA.
Kaeberlein M; Department of Pathology, University of Washington, 98195 Seattle, USA.
Cammue BPA; Centre of Microbial and Plant Genetics, KU Leuven, 3001 Leuven, Belgium; VIB Center for Plant Systems Biology, 9052 Ghent, Belgium.
Thevissen K; Centre of Microbial and Plant Genetics, KU Leuven, 3001 Leuven, Belgium. Electronic address: karin.thevissen@kuleuven.be.

Biochim Biophys Acta Biomembr ; 1862(8): 183255, 2020 08 01.

Article em En | MEDLINE | ID: mdl-32145284

Assuntos

Autofagia/efeitos dos fármacos; Defensinas/química; Heuchera/química; Saccharomyces cerevisiae/efeitos dos fármacos; Antifúngicos/química; Antifúngicos/farmacologia; Apoptose/efeitos dos fármacos; Candida albicans/efeitos dos fármacos; Ciclo Celular/efeitos dos fármacos; Defensinas/genética; Defensinas/farmacologia; Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos; Saccharomyces cerevisiae/genética

Palavras-chave

Autophagy; Cell cycle impairment; GPI-anchored proteins; Vacuolar dysfunction; Yeast

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Autofagia / Defensinas / Heuchera Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Bélgica

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