Pooled analysis of Day 100 survival for defibrotide-treated patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome and ventilator or dialysis dependence following haematopoietic cell transplantation.
Br J Haematol
; 190(4): 583-587, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32157682
ABSTRACT
For patients with untreated hepatic veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS) with multi-organ dysfunction (MOD), mortality is >80%. We conducted a pooled analysis of three studies that assessed Day 100 survival in relationship to MOD severity, with dialysis and/or ventilator dependence representing the most severe organ dysfunction. All patients in the analysis were diagnosed using Baltimore criteria/biopsy. This analysis of patients with VOD/SOS and MOD after haematopoietic cell transplantation (HCT; n = 651) demonstrated higher Day 100 survival rates amongst defibrotide-treated patients with VOD/SOS with less versus more severe forms of MOD. Even patients with severe forms of MOD post-HCT benefitted from defibrotide.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polidesoxirribonucleotídeos
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Respiração Artificial
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Hepatopatia Veno-Oclusiva
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Diálise Renal
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Transplante de Células-Tronco Hematopoéticas
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Condicionamento Pré-Transplante
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Fibrinolíticos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos