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A biosensor based on multifunctional allostery for dynamic analysis of circulating tumor DNA.
Lu, Xing; Wang, Liqian; Chen, Qingxue; Wang, Yulan; Cao, Zhenxiong; Zhou, Guobao; Li, Lei.
Afiliação
  • Lu X; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. lei.li@mail.zjxu.edu.cn gbzhou@mail.zjxu.edu.cn.
  • Wang L; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, P. R. China.
  • Chen Q; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. lei.li@mail.zjxu.edu.cn gbzhou@mail.zjxu.edu.cn.
  • Wang Y; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. lei.li@mail.zjxu.edu.cn gbzhou@mail.zjxu.edu.cn.
  • Cao Z; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. lei.li@mail.zjxu.edu.cn gbzhou@mail.zjxu.edu.cn.
  • Zhou G; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. lei.li@mail.zjxu.edu.cn gbzhou@mail.zjxu.edu.cn.
  • Li L; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China. lei.li@mail.zjxu.edu.cn gbzhou@mail.zjxu.edu.cn.
Chem Commun (Camb) ; 56(30): 4184-4187, 2020 Apr 14.
Article em En | MEDLINE | ID: mdl-32167121
ABSTRACT
Here, a new strategy based on artificial multifunctional allostery (mFA) was explored to regulate the assembly of a DNA nanowire using circulating tumor DNA (ctDNA) as the initiator. Given its unique properties, the mFA-regulated versatile DNA nanowire was applied to engineer a single-step, amplified and dynamic biosensor for the quantitative analysis of ctDNA in serum samples with tunable sensitivity and selectivity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Técnicas Biossensoriais / DNA Tumoral Circulante Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Técnicas Biossensoriais / DNA Tumoral Circulante Idioma: En Ano de publicação: 2020 Tipo de documento: Article