PEST domain NOTCH mutations confer a poor relapse free survival in pediatric T-ALL: Data from a tertiary care centre in India.

Bhatia, Prateek; Totadri, Sidharth; Singh, Minu; Sharma, Praveen; Trehan, Amita; Bansal, Deepak; Jain, Richa; Varma, Neelam; Sachdeva, Manupdesh S; Patra, Nilamani

Bhatia, Prateek; Totadri, Sidharth; Singh, Minu; Sharma, Praveen; Trehan, Amita; Bansal, Deepak; Jain, Richa; Varma, Neelam; Sachdeva, Manupdesh S; Patra, Nilamani.

Afiliação

Bhatia P; Pediatric Hematology-Oncology Unit, Dept. of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address: prateekbhatia@rediffmail.com.
Totadri S; Dept. of Pediatric Hematology-Oncology, Christian Medical College, Vellore, India.
Singh M; Pediatric Hematology-Oncology Unit, Dept. of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Sharma P; Dept. of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Trehan A; Pediatric Hematology-Oncology Unit, Dept. of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Bansal D; Pediatric Hematology-Oncology Unit, Dept. of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Jain R; Pediatric Hematology-Oncology Unit, Dept. of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Varma N; Dept. of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Sachdeva MS; Dept. of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Patra N; Pediatric Hematology-Oncology Unit, Dept. of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Blood Cells Mol Dis ; 82: 102419, 2020 05.

Article em En | MEDLINE | ID: mdl-32179411

Assuntos

Mutação; Leucemia-Linfoma Linfoblástico de Células T Precursoras; Receptor Notch1; Criança; Pré-Escolar; Inibidor de Quinase Dependente de Ciclina p15/genética; Inibidor de Quinase Dependente de Ciclina p15/metabolismo; Inibidor p16 de Quinase Dependente de Ciclina/genética; Inibidor p16 de Quinase Dependente de Ciclina/metabolismo; Intervalo Livre de Doença; Feminino; Seguimentos; Humanos; Índia; Lactente; Masculino; Leucemia-Linfoma Linfoblástico de Células T Precursoras/genética; Leucemia-Linfoma Linfoblástico de Células T Precursoras/metabolismo; Leucemia-Linfoma Linfoblástico de Células T Precursoras/mortalidade; Estudos Prospectivos; Domínios Proteicos; Receptor Notch1/genética; Receptor Notch1/metabolismo; Recidiva; Taxa de Sobrevida; Centros de Atenção Terciária

Palavras-chave

NOTCH1; PEST domain; RFS; T-ALL

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor Notch1 / Leucemia-Linfoma Linfoblástico de Células T Precursoras / Mutação País/Região como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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