The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders.
Dermatol Online J
; 26(2)2020 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-32239884
ABSTRACT
Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity. The pilosebaceous unit is a site for production and metabolism of a number of steroid hormones, including stress and sex hormones. This is an overview of the important role that the cutaneous HPA-like-axis plays in the pathogenesis and treatment of inflammatory pilosebaceous disorders, including acne, rosacea, seborrheic dermatitis, and hidradenitis suppurativa.
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Base de dados:
MEDLINE
Assunto principal:
Sistema Hipófise-Suprarrenal
/
Doenças das Glândulas Sebáceas
/
Sistema Hipotálamo-Hipofisário
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article