Genetic ablation of the mitoribosome in the malaria parasite <i>Plasmodium falciparum</i> sensitizes it to antimalarials that target mitochondrial functions.

Ling, Liqin; Mulaka, Maruthi; Munro, Justin; Dass, Swati; Mather, Michael W; Riscoe, Michael K; Llinás, Manuel; Zhou, Jing; Ke, Hangjun

Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functions.

Ling, Liqin; Mulaka, Maruthi; Munro, Justin; Dass, Swati; Mather, Michael W; Riscoe, Michael K; Llinás, Manuel; Zhou, Jing; Ke, Hangjun.

Afiliação

Ling L; Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129; Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Mulaka M; Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129.
Munro J; Department of Chemistry and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania 16802.
Dass S; Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129.
Mather MW; Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129.
Riscoe MK; Portland Veterans Affairs Medical Center, Portland, Oregon 97239.
Llinás M; Department of Chemistry and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania 16802; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802.
Zhou J; Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: zhoujinghuaxi@163.com.
Ke H; Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129. Electronic address: hk84@drexel.edu.

J Biol Chem ; 295(21): 7235-7248, 2020 05 22.

Article em En | MEDLINE | ID: mdl-32273345

Assuntos

Antimaláricos/farmacologia; Malária Falciparum/metabolismo; Mitocôndrias/metabolismo; Ribossomos Mitocondriais/metabolismo; Plasmodium falciparum/metabolismo; Humanos; Malária Falciparum/tratamento farmacológico; Malária Falciparum/genética; Mitocôndrias/genética; Proteínas Mitocondriais/genética; Proteínas Mitocondriais/metabolismo; Plasmodium falciparum/genética; Proteínas de Protozoários/genética; Proteínas de Protozoários/metabolismo; Proteínas Ribossômicas/genética; Proteínas Ribossômicas/metabolismo

Palavras-chave

CRISPR/Cas; S12; S17; S18; malaria; metabolism; mitochondria; mitochondrial ribosome; mtDNA; plasmodium; ribosome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Malária Falciparum / Ribossomos Mitocondriais / Mitocôndrias / Antimaláricos Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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