Profilin 1 knockdown prevents ischemic brain damage by promoting M2 microglial polarization associated with the RhoA/ROCK pathway.

Lu, Ermei; Wang, Qian; Li, Shengcun; Chen, Caiming; Wu, Weibo; Xu, Yang Xin Zi; Zhou, Peng; Tu, Wenzhan; Lou, Xinfa; Rao, Gaofeng; Yang, Guanhu; Jiang, Songhe; Zhou, Kecheng

Lu, Ermei; Wang, Qian; Li, Shengcun; Chen, Caiming; Wu, Weibo; Xu, Yang Xin Zi; Zhou, Peng; Tu, Wenzhan; Lou, Xinfa; Rao, Gaofeng; Yang, Guanhu; Jiang, Songhe; Zhou, Kecheng.

Afiliação

Lu E; Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Wang Q; Integrative & Optimized Medicine Research Center, Institute for Acupuncture and Rehabilitation, Wenzhou Medical University, Wenzhou, China.
Li S; Department of Pharmacy, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, China.
Chen C; Department of Pharmacy, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, China.
Wu W; Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Xu YXZ; Integrative & Optimized Medicine Research Center, Institute for Acupuncture and Rehabilitation, Wenzhou Medical University, Wenzhou, China.
Zhou P; Department of Pharmacy, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, China.
Tu W; Department of Pharmacy, The First People's Hospital of Wenling, The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling, China.
Lou X; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada.
Rao G; Department of Anatomy, Wenzhou Medical University, Wenzhou, China.
Yang G; Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Jiang S; Integrative & Optimized Medicine Research Center, Institute for Acupuncture and Rehabilitation, Wenzhou Medical University, Wenzhou, China.
Zhou K; Integrative & Optimized Medicine Research Center, Institute for Acupuncture and Rehabilitation, Wenzhou Medical University, Wenzhou, China.

J Neurosci Res ; 98(6): 1198-1212, 2020 06.

Article em En | MEDLINE | ID: mdl-32291804

Assuntos

Isquemia Encefálica/metabolismo; Polaridade Celular/fisiologia; Microglia/metabolismo; Profilinas/metabolismo; Quinases Associadas a rho/metabolismo; Proteína rhoA de Ligação ao GTP/metabolismo; Animais; Isquemia Encefálica/genética; Técnicas de Silenciamento de Genes; Masculino; Camundongos; Profilinas/genética; Transdução de Sinais/fisiologia; Quinases Associadas a rho/genética; Proteína rhoA de Ligação ao GTP/genética

Palavras-chave

actin cytoskeleton; antibodies against ROCK1 (RRID:AB_2238679); antibodies against RhoA (RRID:AB_10693922); antibody against Iba1 (RRID:AB_839504); antibody against ROCK2 (RRID:AB_11127802); antibody against iNOS (RRID:AB_2687529); antibody against profilin 1 (RRID:AB_2163203); antibody against ß-actin (RRID:AB_2797445); ischemic stroke; microglial polarization; neuroinflammation; profilin 1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Polaridade Celular / Microglia / Proteína rhoA de Ligação ao GTP / Profilinas / Quinases Associadas a rho Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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