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Mitochondrial carrier homolog 2 is necessary for AML survival.
Khan, Dilshad H; Mullokandov, Michael; Wu, Yan; Voisin, Veronique; Gronda, Marcela; Hurren, Rose; Wang, Xiaoming; MacLean, Neil; Jeyaraju, Danny V; Jitkova, Yulia; Xu, G Wei; Laister, Rob; Seneviratne, Ayesh; Blatman, Zachary M; Ketela, Troy; Bader, Gary D; Marhon, Sajid A; De Carvalho, Daniel D; Minden, Mark D; Gross, Atan; Schimmer, Aaron D.
Afiliação
  • Khan DH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Mullokandov M; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
  • Wu Y; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Voisin V; The Donnelly Centre, University of Toronto, Toronto, ON, Canada; and.
  • Gronda M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Hurren R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Wang X; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • MacLean N; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Jeyaraju DV; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Jitkova Y; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Xu GW; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Laister R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Seneviratne A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Blatman ZM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Ketela T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Bader GD; The Donnelly Centre, University of Toronto, Toronto, ON, Canada; and.
  • Marhon SA; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • De Carvalho DD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Minden MD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Gross A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
  • Schimmer AD; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Blood ; 136(1): 81-92, 2020 07 02.
Article em En | MEDLINE | ID: mdl-32299104
ABSTRACT
Through a clustered regularly insterspaced short palindromic repeats (CRISPR) screen to identify mitochondrial genes necessary for the growth of acute myeloid leukemia (AML) cells, we identified the mitochondrial outer membrane protein mitochondrial carrier homolog 2 (MTCH2). In AML, knockdown of MTCH2 decreased growth, reduced engraftment potential of stem cells, and induced differentiation. Inhibiting MTCH2 in AML cells increased nuclear pyruvate and pyruvate dehydrogenase (PDH), which induced histone acetylation and subsequently promoted the differentiation of AML cells. Thus, we have defined a new mechanism by which mitochondria and metabolism regulate AML stem cells and gene expression.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Proteínas de Transporte da Membrana Mitocondrial / Mitocôndrias / Proteínas de Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Proteínas de Transporte da Membrana Mitocondrial / Mitocôndrias / Proteínas de Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá