Maturation and phenotype of pathophysiological neuronal excitability of human cells in tau-related dementia.

Kopach, Olga; Esteras, Noemí; Wray, Selina; Rusakov, Dmitri A; Abramov, Andrey Y

Kopach, Olga; Esteras, Noemí; Wray, Selina; Rusakov, Dmitri A; Abramov, Andrey Y.

Afiliação

Kopach O; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK o.kopach@ucl.ac.uk a.abramov@ucl.ac.uk.
Esteras N; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK.
Wray S; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N 1PJ, UK.
Rusakov DA; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK.
Abramov AY; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK o.kopach@ucl.ac.uk a.abramov@ucl.ac.uk.

J Cell Sci ; 133(10)2020 05 27.

Article em En | MEDLINE | ID: mdl-32299835

Assuntos

Demência Frontotemporal; Células-Tronco Pluripotentes Induzidas; Adulto; Demência Frontotemporal/genética; Humanos; Mutação; Neurônios; Fenótipo; Proteínas tau/genética

Palavras-chave

Frontotemporal dementia and parkinsonism; Human cells; Maturation of iPSC-derived neurons; Neuronal excitability; Neuropathological phenotype; Tau pathology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas / Demência Frontotemporal Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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