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Psathyrins: Antibacterial Diterpenoids from Psathyrella candolleana.
Liu, Ya-Pei; Dai, Quan; Wang, Wen-Xuan; He, Juan; Li, Zheng-Hui; Feng, Tao; Liu, Ji-Kai.
Afiliação
  • Liu YP; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
  • Dai Q; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
  • Wang WX; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
  • He J; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
  • Li ZH; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
  • Feng T; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.
  • Liu JK; Institute for Organic Chemistry and Centre for Biomolecular Drug Research, Leibniz University Hannover, Hannover 30167, Germany.
J Nat Prod ; 83(5): 1725-1729, 2020 05 22.
Article em En | MEDLINE | ID: mdl-32330030
ABSTRACT
Two skeletally novel tetracyclic diterpenoids, psathyrins A (1) and B (2), have been characterized from cultures of the basidiomycete Psathyrella candolleana. Their structures including absolute configurations were established by means of spectroscopic methods, as well as ECD calculations. They possess a novel 5/5/4/6-fuesd ring system, for which the biosynthetic pathway is proposed. Compounds 1 and 2 inhibited the growth of Staphylococcus aureus and Salmonella enterica.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Basidiomycota / Diterpenos / Antibacterianos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Basidiomycota / Diterpenos / Antibacterianos Idioma: En Ano de publicação: 2020 Tipo de documento: Article