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A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.
Christensen, Nikolaj R; De Luca, Marta; Lever, Michael B; Richner, Mette; Hansen, Astrid B; Noes-Holt, Gith; Jensen, Kathrine L; Rathje, Mette; Jensen, Dennis Bo; Erlendsson, Simon; Bartling, Christian Ro; Ammendrup-Johnsen, Ina; Pedersen, Sofie E; Schönauer, Michèle; Nissen, Klaus B; Midtgaard, Søren R; Teilum, Kaare; Arleth, Lise; Sørensen, Andreas T; Bach, Anders; Strømgaard, Kristian; Meehan, Claire F; Vaegter, Christian B; Gether, Ulrik; Madsen, Kenneth L.
Afiliação
  • Christensen NR; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • De Luca M; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Lever MB; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Richner M; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Hansen AB; Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
  • Noes-Holt G; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Jensen KL; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Rathje M; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Jensen DB; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Erlendsson S; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Bartling CR; Structural biology and NMR Laboratory, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Ammendrup-Johnsen I; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Pedersen SE; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Schönauer M; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Nissen KB; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Midtgaard SR; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Teilum K; Structural Biophysics, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark.
  • Arleth L; Structural biology and NMR Laboratory, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Sørensen AT; Structural Biophysics, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark.
  • Bach A; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Strømgaard K; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Meehan CF; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Vaegter CB; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Gether U; Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
  • Madsen KL; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
EMBO Mol Med ; 12(6): e11248, 2020 06 08.
Article em En | MEDLINE | ID: mdl-32352640
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Domínios PDZ / Neuralgia Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Domínios PDZ / Neuralgia Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Dinamarca