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De novo protein design enables the precise induction of RSV-neutralizing antibodies.
Sesterhenn, Fabian; Yang, Che; Bonet, Jaume; Cramer, Johannes T; Wen, Xiaolin; Wang, Yimeng; Chiang, Chi-I; Abriata, Luciano A; Kucharska, Iga; Castoro, Giacomo; Vollers, Sabrina S; Galloux, Marie; Dheilly, Elie; Rosset, Stéphane; Corthésy, Patricia; Georgeon, Sandrine; Villard, Mélanie; Richard, Charles-Adrien; Descamps, Delphyne; Delgado, Teresa; Oricchio, Elisa; Rameix-Welti, Marie-Anne; Más, Vicente; Ervin, Sean; Eléouët, Jean-François; Riffault, Sabine; Bates, John T; Julien, Jean-Philippe; Li, Yuxing; Jardetzky, Theodore; Krey, Thomas; Correia, Bruno E.
Afiliação
  • Sesterhenn F; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
  • Yang C; Swiss Institute of Bioinformatics (SIB), Lausanne CH-1015, Switzerland.
  • Bonet J; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
  • Cramer JT; Swiss Institute of Bioinformatics (SIB), Lausanne CH-1015, Switzerland.
  • Wen X; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
  • Wang Y; Swiss Institute of Bioinformatics (SIB), Lausanne CH-1015, Switzerland.
  • Chiang CI; Institute of Virology, Hannover Medical School, Hannover 30625, Germany.
  • Abriata LA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Kucharska I; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA.
  • Castoro G; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA.
  • Vollers SS; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
  • Galloux M; Swiss Institute of Bioinformatics (SIB), Lausanne CH-1015, Switzerland.
  • Dheilly E; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada.
  • Rosset S; Departments of Biochemistry and Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Corthésy P; Institute of Virology, Hannover Medical School, Hannover 30625, Germany.
  • Georgeon S; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
  • Villard M; Swiss Institute of Bioinformatics (SIB), Lausanne CH-1015, Switzerland.
  • Richard CA; Université Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.
  • Descamps D; Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
  • Delgado T; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
  • Oricchio E; Swiss Institute of Bioinformatics (SIB), Lausanne CH-1015, Switzerland.
  • Rameix-Welti MA; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
  • Más V; Swiss Institute of Bioinformatics (SIB), Lausanne CH-1015, Switzerland.
  • Ervin S; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
  • Eléouët JF; Swiss Institute of Bioinformatics (SIB), Lausanne CH-1015, Switzerland.
  • Riffault S; Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
  • Bates JT; Swiss Institute of Bioinformatics (SIB), Lausanne CH-1015, Switzerland.
  • Julien JP; Université Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.
  • Li Y; Université Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.
  • Jardetzky T; Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Madrid, Spain.
  • Krey T; Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne CH-1015, Switzerland.
  • Correia BE; UMR1173, INSERM, Université de Versailles St. Quentin, 78180 Montigny le Bretonneux, France.
Science ; 368(6492)2020 05 15.
Article em En | MEDLINE | ID: mdl-32409444
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Engenharia de Proteínas / Epitopos Imunodominantes / Vírus Sincicial Respiratório Humano / Biologia Computacional / Vacinas contra Vírus Sincicial Respiratório / Anticorpos Neutralizantes Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Engenharia de Proteínas / Epitopos Imunodominantes / Vírus Sincicial Respiratório Humano / Biologia Computacional / Vacinas contra Vírus Sincicial Respiratório / Anticorpos Neutralizantes Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça