Quantitative adverse outcome pathway (qAOP) models for toxicity prediction.

Spinu, Nicoleta; Cronin, Mark T D; Enoch, Steven J; Madden, Judith C; Worth, Andrew P

Spinu, Nicoleta; Cronin, Mark T D; Enoch, Steven J; Madden, Judith C; Worth, Andrew P.

Afiliação

Spinu N; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.
Cronin MTD; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.
Enoch SJ; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.
Madden JC; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.
Worth AP; European Commission, Joint Research Centre (JRC), Ispra, Italy. andrew.worth@ec.europa.eu.

Arch Toxicol ; 94(5): 1497-1510, 2020 05.

Article em En | MEDLINE | ID: mdl-32424443

Assuntos

Rotas de Resultados Adversos; Testes de Toxicidade; Animais; Previsões; Humanos; Medição de Risco; Software

Palavras-chave

Bayesian network; Computational approach; Key event relationship; Predictive toxicology; Quantitative adverse outcome pathway (qAOP); Response-response relationship

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Testes de Toxicidade / Rotas de Resultados Adversos Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido

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