Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy.
Neuroimage
; 218: 116967, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-32445879
ABSTRACT
BACKGROUND:
Bilateral cyclic high frequency deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) reduces the seizure count in a subset of patients with epilepsy. Detecting stimulation-induced alterations of pathological brain networks may help to unravel the underlying physiological mechanisms related to effective stimulation delivery and optimize target engagement.METHODS:
We acquired 64-channel electroencephalography during ten ANT-DBS cycles (145 âHz, 90 âµs, 3-5 âV) of 1-min ON followed by 5-min OFF stimulation to detect changes in cortical activity related to seizure reduction. The study included 14 subjects (three responders, four non-responders, and seven healthy controls). Mixed-model ANOVA tests were used to compare differences in cortical activity between subgroups both ON and OFF stimulation, while investigating frequency-specific effects for the seizure onset zones.RESULTS:
ANT-DBS had a widespread desynchronization effect on cortical theta and alpha band activity in responders, but not in non-responders. Time domain analysis showed that the stimulation induced reduction in theta-band activity was temporally linked to the stimulation period. Moreover, stimulation induced theta-band desynchronization in the temporal lobe channels correlated significantly with the therapeutic response. Responders to ANT-DBS and healthy-controls had an overall lower level of theta-band activity compared to non-responders.CONCLUSION:
This study demonstrated that temporal lobe channel theta-band desynchronization may be a predictive physiological hallmark of therapeutic response to ANT-DBS and may be used to improve the functional precision of this intervention by verifying implantation sites, calibrating stimulation contacts, and possibly identifying treatment responders prior to implantation.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lobo Temporal
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Ritmo Teta
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Núcleos Anteriores do Tálamo
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Estimulação Encefálica Profunda
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Epilepsia
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Sincronização de Fases em Eletroencefalografia
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha