GL2 EXPRESSION MODULATOR, a plant specific protein phosphatase one interactor that binds phosphoinositides.
Biochem Biophys Res Commun
; 528(3): 607-611, 2020 07 30.
Article
em En
| MEDLINE
| ID: mdl-32513542
ABSTRACT
Protein phosphatase one (PP1) is a major eukaryotic serine/threonine protein phosphatase whose activity is controlled by targeting or regulatory subunits. Currently, very few plant protein phosphatase one regulatory subunits are known. Here, Arabidopsis GL2 EXPRESSION MODULATOR (GEM) was identified and confirmed as a protein phosphatase one binding partner. GEM is a phosphoprotein, contains a highly conserved phosphoinositide binding GRAM domain and a classic protein phosphatase one binding RVXF motif. Lipid overlays show GEM has the ability to interact with phosphoinositides through its GRAM domain. GEM is the first plant specific protein phosphatase one interactor to be discovered.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilinositóis
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Arabidopsis
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Proteínas de Arabidopsis
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Peptídeos e Proteínas de Sinalização Intracelular
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Canadá