Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases.
Trends Biochem Sci
; 45(7): 578-592, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32531228
ABSTRACT
Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases. New studies have illustrated the promising feasibility and safety to selectively ablate senescent cells from tissues, a therapeutic modality that holds potential for treating multiple chronic pathologies and extending human healthspan. Here, we review molecular links between cellular senescence and age-associated complications and highlight novel therapeutic avenues that may be exploited to target senescent cells in future geriatric medicine.
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Base de dados:
MEDLINE
Assunto principal:
Senescência Celular
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article