Photo-cross-linkable, insulating silk fibroin for bioelectronics with enhanced cell affinity.
Proc Natl Acad Sci U S A
; 117(27): 15482-15489, 2020 07 07.
Article
em En
| MEDLINE
| ID: mdl-32571918
Bioelectronic scaffolds that support devices while promoting tissue integration could enable tissue hybrids with augmented electronic capabilities. Here, we demonstrate a photo-cross-linkable silk fibroin (PSF) derivative and investigate its structural, electrical, and chemical properties. Lithographically defined PSF films offered tunable thickness and <1-µm spatial resolution and could be released from a relief layer yielding freestanding scaffolds with centimeter-scale uniformity. These constructs were electrically insulating; multielectrode arrays with PSF-passivated interconnects provided stable electrophysiological readouts from HL-1 cardiac model cells, brain slices, and hearts. Compared to SU8, a ubiquitous biomaterial, PSF exhibited superior affinity toward neurons which we attribute to its favorable surface charge and enhanced attachment of poly-d-lysine adhesion factors. This finding is of significant importance in bioelectronics, where tight junctions between devices and cell membranes are necessary for electronic communication. Collectively, our findings are generalizable to a variety of geometries, devices, and tissues, establishing PSF as a promising bioelectronic platform.
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MEDLINE
Assunto principal:
Materiais Biocompatíveis
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Fontes de Energia Bioelétrica
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Engenharia Tecidual
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Alicerces Teciduais
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Fibroínas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article