A combined CaMKII inhibition and mineralocorticoid receptor antagonism via eplerenone inhibits functional deterioration in chronic pressure overloaded mice.

Driessen, Helen E; Fontes, Magda S; van Stuijvenberg, Leonie; Brans, Maike A; Goumans, Marie-Jose; Vos, Marc A; van Veen, Toon A

Driessen, Helen E; Fontes, Magda S; van Stuijvenberg, Leonie; Brans, Maike A; Goumans, Marie-Jose; Vos, Marc A; van Veen, Toon A.

Afiliação

Driessen HE; Division of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Fontes MS; Division of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
van Stuijvenberg L; Division of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Brans MA; Division of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Goumans MJ; Department of Cell and Chemical Biology, LUMC, Leiden, The Netherlands.
Vos MA; Division of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.
van Veen TA; Division of Heart & Lungs, Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands.

J Cell Mol Med ; 24(15): 8417-8429, 2020 08.

Article em En | MEDLINE | ID: mdl-32573944

Assuntos

Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo; Eplerenona/farmacologia; Antagonistas de Receptores de Mineralocorticoides/farmacologia; Receptores de Mineralocorticoides/metabolismo; Animais; Arritmias Cardíacas/metabolismo; Sinalização do Cálcio/efeitos dos fármacos; Modelos Animais de Doenças; Feminino; Fibrose/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Transdução de Sinais/efeitos dos fármacos; Proteína Smad3/metabolismo; Fator de Crescimento Transformador beta/metabolismo

Palavras-chave

CaMKII; contractile performance; echocardiography; heart failure; mineralocorticoid receptor antagonism; patchy fibrosis; strain analysis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Mineralocorticoides / Antagonistas de Receptores de Mineralocorticoides / Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina / Eplerenona Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

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