S(+)-(2E)-N-(2-Hydroxypropyl)-3-Phenylprop-2-Enamide (KM-568): A Novel Cinnamamide Derivative with Anticonvulsant Activity in Animal Models of Seizures and Epilepsy.

Gunia-Krzyzak, Agnieszka; Zeslawska, Ewa; Sloczynska, Karolina; Zelaszczyk, Dorota; Sowa, Aleksandra; Koczurkiewicz-Adamczyk, Paulina; Popiól, Justyna; Nitek, Wojciech; Pekala, Elzbieta; Marona, Henryk

Gunia-Krzyzak, Agnieszka; Zeslawska, Ewa; Sloczynska, Karolina; Zelaszczyk, Dorota; Sowa, Aleksandra; Koczurkiewicz-Adamczyk, Paulina; Popiól, Justyna; Nitek, Wojciech; Pekala, Elzbieta; Marona, Henryk.

Afiliação

Gunia-Krzyzak A; Jagiellonian University Medical College, Faculty of Pharmacy, Chair of Organic Chemistry, Department of Bioorganic Chemistry, Medyczna 9, 30-688 Kraków, Poland.
Zeslawska E; Pedagogical University, Institute of Biology, Podchorazych 2, 30-084 Kraków, Poland.
Sloczynska K; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry, Medyczna 9, 30-688 Kraków, Poland.
Zelaszczyk D; Jagiellonian University Medical College, Faculty of Pharmacy, Chair of Organic Chemistry, Department of Bioorganic Chemistry, Medyczna 9, 30-688 Kraków, Poland.
Sowa A; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry, Medyczna 9, 30-688 Kraków, Poland.
Koczurkiewicz-Adamczyk P; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry, Medyczna 9, 30-688 Kraków, Poland.
Popiól J; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry, Medyczna 9, 30-688 Kraków, Poland.
Nitek W; Jagiellonian University, Faculty of Chemistry, Gronostajowa 2, 30-387 Kraków, Poland.
Pekala E; Jagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmaceutical Biochemistry, Medyczna 9, 30-688 Kraków, Poland.
Marona H; Jagiellonian University Medical College, Faculty of Pharmacy, Chair of Organic Chemistry, Department of Bioorganic Chemistry, Medyczna 9, 30-688 Kraków, Poland.

Int J Mol Sci ; 21(12)2020 Jun 19.

Article em En | MEDLINE | ID: mdl-32575479

Assuntos

Anticonvulsivantes/administração & dosagem; Cinamatos/administração & dosagem; Epilepsia/tratamento farmacológico; Convulsões/tratamento farmacológico; Animais; Anticonvulsivantes/síntese química; Anticonvulsivantes/química; Anticonvulsivantes/uso terapêutico; Linhagem Celular; Cinamatos/síntese química; Cinamatos/química; Cinamatos/uso terapêutico; Cristalografia; Modelos Animais de Doenças; Epilepsia/etiologia; Células Hep G2; Humanos; Injeções Intraperitoneais; Masculino; Camundongos; Estrutura Molecular; Ratos; Convulsões/etiologia

Palavras-chave

anticonvulsant; antiseizure, cinnamamide derivatives; crystallography; drug development; epilepsy; preclinical safety evaluation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Convulsões / Cinamatos / Epilepsia / Anticonvulsivantes Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Polônia

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