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Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity.
Panyain, Nattawadee; Godinat, Aurélien; Lanyon-Hogg, Thomas; Lachiondo-Ortega, Sofía; Will, Edward J; Soudy, Christelle; Mondal, Milon; Mason, Katie; Elkhalifa, Sarah; Smith, Lisa M; Harrigan, Jeanine A; Tate, Edward W.
Afiliação
  • Panyain N; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, U.K.
  • Godinat A; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, U.K.
  • Lanyon-Hogg T; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, U.K.
  • Lachiondo-Ortega S; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, U.K.
  • Will EJ; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, U.K.
  • Soudy C; The Francis Crick Institute, London, NW1 1AT, U.K.
  • Mondal M; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, U.K.
  • Mason K; Mission Therapeutics Ltd, Moneta, Babraham Research Campus, Cambridge, CB22 3AT, U.K.
  • Elkhalifa S; Mission Therapeutics Ltd, Moneta, Babraham Research Campus, Cambridge, CB22 3AT, U.K.
  • Smith LM; Mission Therapeutics Ltd, Moneta, Babraham Research Campus, Cambridge, CB22 3AT, U.K.
  • Harrigan JA; Mission Therapeutics Ltd, Moneta, Babraham Research Campus, Cambridge, CB22 3AT, U.K.
  • Tate EW; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, U.K.
J Am Chem Soc ; 142(28): 12020-12026, 2020 07 15.
Article em En | MEDLINE | ID: mdl-32579346
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ubiquitina Tiolesterase / Inibidores Enzimáticos / Descoberta de Drogas Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ubiquitina Tiolesterase / Inibidores Enzimáticos / Descoberta de Drogas Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido