Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells.

Louisse, Jochem; Rijkers, Deborah; Stoopen, Geert; Janssen, Aafke; Staats, Martijn; Hoogenboom, Ron; Kersten, Sander; Peijnenburg, Ad

Louisse, Jochem; Rijkers, Deborah; Stoopen, Geert; Janssen, Aafke; Staats, Martijn; Hoogenboom, Ron; Kersten, Sander; Peijnenburg, Ad.

Afiliação

Louisse J; Wageningen Food Safety Research (WFSR), Wageningen, The Netherlands. jochem.louisse@wur.nl.
Rijkers D; Wageningen Food Safety Research (WFSR), Wageningen, The Netherlands.
Stoopen G; Wageningen Food Safety Research (WFSR), Wageningen, The Netherlands.
Janssen A; Wageningen Food Safety Research (WFSR), Wageningen, The Netherlands.
Staats M; Wageningen Food Safety Research (WFSR), Wageningen, The Netherlands.
Hoogenboom R; Wageningen Food Safety Research (WFSR), Wageningen, The Netherlands.
Kersten S; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Peijnenburg A; Wageningen Food Safety Research (WFSR), Wageningen, The Netherlands.

Arch Toxicol ; 94(9): 3137-3155, 2020 09.

Article em En | MEDLINE | ID: mdl-32588087

Assuntos

Poluentes Ambientais/toxicidade; Fluorocarbonos/toxicidade; Triglicerídeos/metabolismo; Ácidos Alcanossulfônicos/toxicidade; Caprilatos/toxicidade; Colesterol; Ácidos Graxos; Expressão Gênica/efeitos dos fármacos; Hepatócitos; Humanos; Fígado; PPAR alfa

Palavras-chave

Cholesterol; HepaRG cells; PFASs; Transcriptomics; Triglycerides

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triglicerídeos / Poluentes Ambientais / Fluorocarbonos Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google