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Sex-dependent grades of haematopoietic modulation in patients with major depressive episodes are associated with suicide attempts.
Martínez-Botía, Patricia; Velasco, Angela; Rolle, Valeria; Jiménez-Trevino, Luis; De la Fuente-Tomás, Lorena; Bernardo, Ángel; Arias, Tamara; Muñoz-Turrillas, María Del Carmen; García-Alvarez, Leticia; González-Blanco, Leticia; Rodríguez-Revuelta, Julia; Garcia-Portilla, Maria Paz; Courtet, Philippe; Bobes, Julio; Gutiérrez, Laura; Sáiz, Pilar Alejandra.
Afiliação
  • Martínez-Botía P; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Department of Medicine, Universidad de Oviedo, Spain.
  • Velasco A; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Department of Psychiatry, Universidad de Oviedo, Spain; Biomedical Research Networking Centre in Mental Health (CIBERSAM), Oviedo, Spain.
  • Rolle V; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
  • Jiménez-Trevino L; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Department of Psychiatry, Universidad de Oviedo, Spain; Biomedical Research Networking Centre in Mental Health (CIBERSAM), Oviedo, Spain; Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain.
  • De la Fuente-Tomás L; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Department of Psychiatry, Universidad de Oviedo, Spain; Biomedical Research Networking Centre in Mental Health (CIBERSAM), Oviedo, Spain.
  • Bernardo Á; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Hospital Universitario Central de Asturias, Laboratorio de Diagnóstico Clínico Hematología, Oviedo, Spain.
  • Arias T; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Centro Comunitario de Sangre y Tejidos de Asturias, Oviedo, Spain.
  • Muñoz-Turrillas MDC; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Centro Comunitario de Sangre y Tejidos de Asturias, Oviedo, Spain.
  • García-Alvarez L; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Biomedical Research Networking Centre in Mental Health (CIBERSAM), Oviedo, Spain.
  • González-Blanco L; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Department of Psychiatry, Universidad de Oviedo, Spain; Biomedical Research Networking Centre in Mental Health (CIBERSAM), Oviedo, Spain; Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain.
  • Rodríguez-Revuelta J; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Department of Psychiatry, Universidad de Oviedo, Spain; Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain.
  • Garcia-Portilla MP; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Department of Psychiatry, Universidad de Oviedo, Spain; Biomedical Research Networking Centre in Mental Health (CIBERSAM), Oviedo, Spain; Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain.
  • Courtet P; Department of Emergency Psychiatry & Post-Acute Care, Lapeyronie Hospital, CHU Montpellier - Inserm U1061, University of Montpellier, Montpellier, France; Fondation FondaMental, Créteil, France.
  • Bobes J; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Department of Psychiatry, Universidad de Oviedo, Spain; Biomedical Research Networking Centre in Mental Health (CIBERSAM), Oviedo, Spain; Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain.
  • Gutiérrez L; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Department of Medicine, Universidad de Oviedo, Spain. Electronic address: gutierrezglaura@uniovi.es.
  • Sáiz PA; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Department of Psychiatry, Universidad de Oviedo, Spain; Biomedical Research Networking Centre in Mental Health (CIBERSAM), Oviedo, Spain; Servicio de Salud del Principado de Asturias (SESPA), Oviedo, Spain. Electr
Eur Neuropsychopharmacol ; 40: 17-30, 2020 11.
Article em En | MEDLINE | ID: mdl-32600963
Suicide is the leading cause of non-natural death worldwide, and major depressive disorder (MDD) is the mood disorder with the highest prevalence among individuals with suicidal behaviour (SB). The role of inflammation and immunomodulation in mood disorders has raised interest in recent years, as inflammation biomarkers have been reported to be increased in mood disorder patients, suggesting a role of inflammation in their pathogenesis. The influence of inflammation on the haematopoietic production is well known; however, a comprehensive study of the haematopoietic production in patients with major depressive episodes (MDE) is lacking. We examined global haematopoietic parameters from complete blood counts (CBC) of patients with MDE, in search of prognostic patterns. MDE patients presented differences in several CBC parameters, differences that were clearly pronounced and/or significant in concurrence with suicide attempts (SA). Red and white blood cell lineage parameters were affected, suggesting general haematopoietic modulation or imbalance. We observed distinct haematological parameter changes in women versus men, with men presenting milder alterations than women. Interestingly, we found that the List of Threatening Experiences (LTE) score, but not the Childhood Trauma Questionnaire (CTQ), was associated with the haematopoietic alterations observed exclusively in women and, more importantly, served as a parameter to stratify female MDE patients based on concurrence or non-concurrence with SA. In conclusion, grades of haematopoietic modulation in MDE patients are associated with absence or presence of SA. Haematopoietic manifestations differ between men and women and, in the latter, are markedly influenced by late, and not early, traumatic events.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tentativa de Suicídio / Caracteres Sexuais / Análise de Componente Principal / Transtorno Depressivo Maior / Hematopoese Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tentativa de Suicídio / Caracteres Sexuais / Análise de Componente Principal / Transtorno Depressivo Maior / Hematopoese Idioma: En Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha