Altered slow-wave sleep activity in children with rapid-onset obesity with hypothalamic dysregulation, hypoventilation, and autonomic dysregulation syndrome.
J Clin Sleep Med
; 16(10): 1731-1735, 2020 10 15.
Article
em En
| MEDLINE
| ID: mdl-32638701
ABSTRACT
STUDY OBJECTIVES:
Rapid-onset obesity with hypothalamic dysregulation, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare condition. Little is known about sleep/wake and slow-wave activity in this condition, although the central hypothalamic dysfunction associated with autonomic dysregulation would make the occurrence of SWA deregulation most likely.METHODS:
Two children with clinical presentation of ROHHAD syndrome were evaluated, diagnosed, and treated. Their polysomnographic studies were compared with 4 matched children with obstructive sleep apnea and 6 controls.RESULTS:
Children that were clinically diagnosed with ROHHAD exhibited significantly weaker slow-wave activity power and shallower slow-wave activity slopes during the first 2 sleep cycles compared with children with obstructive sleep apnea or controls.CONCLUSIONS:
This study shows that children with ROHHAD have suppressed slow-wave activity, possibly because of hypothalamic dysregulation that may contribute to their rapid-onset obesity and excessive daytime sleepiness.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Hipoventilação por Obesidade
/
Doenças do Sistema Nervoso Autônomo
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Sono de Ondas Lentas
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Doenças Hipotalâmicas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Israel