Fas ligand neutralization attenuates hypertension, endothelin-1, and placental inflammation in an animal model of HELLP syndrome.

Gibbens, Jacob; Spencer, Shauna-Kay; Solis, Lucia; Bowles, Teylor; Kyle, Patrick B; Szczepanski, Jamie L; Dumas, John Polk; Robinson, Reanna; Wallace, Kedra

Gibbens, Jacob; Spencer, Shauna-Kay; Solis, Lucia; Bowles, Teylor; Kyle, Patrick B; Szczepanski, Jamie L; Dumas, John Polk; Robinson, Reanna; Wallace, Kedra.

Afiliação

Gibbens J; Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Spencer SK; Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Solis L; Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Bowles T; Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Kyle PB; Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi.
Szczepanski JL; Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Dumas JP; Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Robinson R; Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Wallace K; Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.

Am J Physiol Regul Integr Comp Physiol ; 319(2): R195-R202, 2020 08 01.

Article em En | MEDLINE | ID: mdl-32640833

Assuntos

Anticorpos Neutralizantes/uso terapêutico; Endotelina-1/sangue; Proteína Ligante Fas/imunologia; Síndrome HELLP/tratamento farmacológico; Placenta/fisiopatologia; Animais; Modelos Animais de Doenças; Proteína Ligante Fas/sangue; Feminino; Síndrome HELLP/sangue; Síndrome HELLP/imunologia; Síndrome HELLP/fisiopatologia; Imunoglobulina G; Placenta/imunologia; Gravidez; Ratos; Ratos Sprague-Dawley; Resultado do Tratamento; Fator de Necrose Tumoral alfa/sangue; Receptor 1 de Fatores de Crescimento do Endotélio Vascular/sangue

Palavras-chave

Fas; HELLP syndrome; TNF; hypertension; preeclampsia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Síndrome HELLP / Endotelina-1 / Proteína Ligante Fas / Anticorpos Neutralizantes Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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